Base de dados : HANSEN
Pesquisa : CAMUNDONGOS ENDOGAMICOS C57BL [Descritor de assunto]
Referências encontradas : 10 [refinar]
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Id:18953
Autor:Bochud, Pierre-Yves; Hawn, Thomas R; Aderem, Alan
Título:Cutting edge: a toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling
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Fonte:s.l; s.n; 2003. 4 p. graf.
Resumo:Toll-like receptors (TLRs) are key mediators of the innate immune response to microbial pathogens. We investigated the role of TLRs in the recognition of Mycobacterium leprae and the significance of TLR2Arg(677)Trp, a recently discovered human polymorphism that is associated with lepromatous leprosy. In mice, TNF-alpha production in response to M. leprae was essentially absent in TLR2-deficient macrophages. Similarly, human TLR2 mediated M. leprae-dependent activation of NF-kappaB in transfected Chinese hamster ovary and human embryonic kidney 293 cells, with enhancement of this signaling in the presence of CD14. In contrast, activation of NF-kappaB by human TLR2Arg(677)Trp was abolished in response to M. leprae and Mycobacterium tuberculosis. The impaired function of this TLR2 variant provides a molecular mechanism for the poor cellular immune response associated with lepromatous leprosy and may have important implications for understanding the pathogenesis of other mycobacterial infections. (AU).
Descritores:CELULAS CHO
LINHAGEM CELULAR
IMUNIDADE NATURAL/genet
ARGININA/genet
HANSENIASE VIRCHOWIANA/genet
HANSENIASE VIRCHOWIANA/imunol
HANSENIASE VIRCHOWIANA/microbiol
GLICOPROTEINAS DE MEMBRANA/defic
GLICOPROTEINAS DE MEMBRANA/genet
GLICOPROTEINAS DE MEMBRANA/fisiol
CAMUNDONGOS ENDOGÂMICOS C57BL
CAMUNDONGOS KNOCKOUT
MYCOBACTERIUM LEPRAE/imunol
MYCOBACTERIUM TUBERCULOSIS/imunol
POLIMORFISMO DE UM UNICO NUCLEOTIDIO/imunol
TRANSDUCAO DE SINAL/imunol
TRIPTOFANO/genet
RECEPTORES DA SUPERFICIE CELULAR/defic
RECEPTORES DA SUPERFICIE CELULAR/genet
RECEPTORES DA SUPERFICIE CELULAR/fisiol
Limites:HUMANO
ANIMAL
HAMSTERS
CAMUNDONGOS
SUPPORT, NON-U.S. GOV'T
SUPPORT, U.S. GOV'T, P.H.S.
Meio Eletrônico: - .
Localização:BR191.1; 09085/s


  2 / 10 HANSEN  
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Id:18133
Autor:Closs, O; Kronvall, G
Título:Experimental murine leprosy
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Fonte:s.l; s.n; 1975. 6 p. ilus, tab.
Resumo:Sera from C3H and C57BL mice infected with Mycobacterium lepraemurium (MLM) and from human leprosy patients were examined for antibodies against MLM by a crossed immunoelectrophoresis (CIE) technique. Altogether antibodies against six or seven MLM antigens were found in the mouse sera. After a small inoculum of MLM, C3H mice produced more antibodies than C57BL mice. After a large inoculum both strains produced about the same amount of antibodies but showed qualitative differences in their response patterns. A serum pool from patients with lepromatous leprosy contained antibodies against six MLM antigens; five of these were identical with the antigens against which antibodies were found in infected mice. C57BL mice that had lost their delayed-type hypersensitivity to MLM during the course of a disseminated infection showed a fairly strong antibody response to three antigens and a weak response to three others. Since almost the same spectrum of antibodies, although in lower titres, could be demonstrated in C57BL mice with intact delayed-type hypersensitivity to the bacilli, these antibodies did not seem to interfere with the expression of cell-mediated immunity.(AU).
Descritores:MODELOS ANIMAIS DE DOENCAS
ANTIGENOS DE BACTERIAS
ANTICORPOS ANTIBACTERIAS
HIPERSENSIBILIDADE TARDIA/imunol
IMUNIDADE CELULAR
IMUNOELETROFORESE BIDIMENSIONAL
HANSENIASE/imunol
CAMUNDONGOS ENDOGÂMICOS C3H/imunol
CAMUNDONGOS ENDOGÂMICOS C57BL/imunol
MYCOBACTERIUM LEPRAEMURIUM/imunol
Limites:HUMANO
ANIMAL
FEMININO
CAMUNDONGOS
Meio Eletrônico: - .
Localização:BR191.1; 00024/s


  3 / 10 HANSEN  
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Id:16385
Autor:Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi
Título:Protective responses against experimental mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates
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Fonte:s.l; s.n; Feb. 2001. 5 p. ilus, graf.
Descritores:ANTIGENOS DE BACTÉRIAS
VACINA BCG
VACINA BCG
VACINA BCG
SEQUENCIA DE BASES
PRIMERS DO DNA
HANSENIASE
HANSENIASE
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS BALB C
CAMUNDONGOS ENDOGAMICOS C57BL
MYCOBACTERIUM BOVIS
MYCOBACTERIUM BOVIS
Limites:ANIMAL
Localização:BR191.1; 08623/s


  4 / 10 HANSEN  
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Id:16337
Autor:Rambukkana, Anura; Zanazzi, George; Tapinos, Nikos; Salzer, James L
Título:Contact-dependent demyelination by mycobacterium leprae in the absence of immune cells
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Fonte:s.l; s.n; May 2002. 5 p. ilus, graf.
Descritores:APOPTOSE
AXONIOS
AXONIOS
LINFOCITOS B
ADERENCIA BACTERIANA
DIVISAO CELULAR
COCULTURA
DOENÇAS DESMIELINIZANTES
GANGLIOS ESPINHAIS
GENES RAG-1
GLICOLIPIDIOS
HANSENIASE
HANSENIASE
HANSENIASE
HANSENIASE
MACROFAGOS
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS C57BL
CAMUNDONGOS KNOCKOUT
MUTAÇAO
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
BAINHA DE MIELINA
BAINHA DE MIELINA
DEGENERAÇAO NEURAL
FIBRAS NERVOSAS MIELINIZADAS
NEURONIOS
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
NERVO CIATICO
NERVO CIATICO
LINFOCITOS T
CULTURA DE TECIDO
Limites:ANIMAL
Localização:BR191.1; 08647/s


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Id:15742
Autor:Ohara, Naoya; Matsuoka, Masanori; Nomaguchi, Hiroko; Naito, Mariko; Yamada, Takeshi
Título:Protective responses against experimental Mycobacterium leprae infection in mice induced by recombinant Bacillus Calmette-Guérin over-producing three putative protective antigen candidates
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Fonte:s.l; s.n; 2001. 5 p. ilus, graf.
Descritores:MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM LEPRAE
MYCOBACTERIUM BOVIS
MYCOBACTERIUM BOVIS
HANSENIASE
HANSENIASE
ANTIGENOS DE BACTÉRIAS
VACINA BCG
VACINA BCG
VACINA BCG
SEQUENCIA DE BASES
PRIMERS DO DNA
CAMUNDONGOS ENDOGAMICOS BALB C
CAMUNDONGOS ENDOGAMICOS C57BL
PLASMIDEOS
BAÇO
Limites:ANIMAL
MASCULINO
CAMUNDONGOS
Localização:BR191.1; 08478/s


  6 / 10 HANSEN  
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Id:14381
Autor:Singh, N; Birdi, T. J; Antia, N. H
Título:Nerve growth factor production and expression of p75 by Schwann cells and neurofibroblasts in response to M. leprae infection and macrophage secretory products
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Fonte:s.l; s.n; 1997. 9 p. ilus, tab, graf.
Descritores:ELISA
FIBROBLASTOS
HANSENIASE
MACROFAGOS
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS C57BL
PROTEINAS ONCOGENICAS V-FOS
CÉLULAS DE SCHWANN
Fatores de Crescimento Neural/*ME
Limites:ANIMAL
Localização:BR191.1; 07507/s


  7 / 10 HANSEN  
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Id:14271
Autor:Singh, Neeta; Birdi, Tannaz J; Antia, Noshir H
Título:Differential in vitro modulation of schwann cell proliferation by mycobacterium leprae and macrophages in the murine strains, Swiss white and C57BI/6
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Fonte:s.l; s.n; 1998. 10 p. tab, graf.
Descritores:DIVISAO CELULAR
COCULTURA
HANSENIASE
MACROFAGOS
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS C57BL
MYCOBACTERIUM LEPRAE
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
CÉLULAS DE SCHWANN
CELULAS CULTIVADAS
Limites:ANIMAL
Localização:BR191.1; 07165/s


  8 / 10 HANSEN  
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Id:14104
Autor:Moura, A. C. N; Modolell, M; Mariano, M
Título:Down-regulatory effect of Mycobacterium leprae cell wall lipids on phagocytosis, oxidative respiratory burst and tumour cell killing by mouse bone marrow derived macrophages
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Fonte:s.l; s.n; 1997. 6 p. ilus, tab, graf.
Descritores:PAREDE CELULAR
DEPRESSAO QUIMICA
HANSENIASE
LIPIDIOS
LIPIDIOS
LIPOSSOMOS
ATIVAÇAO DE MACROFAGOS
MACROFAGOS
MACROFAGOS
MACROFAGOS
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS BALB C
CAMUNDONGOS ENDOGAMICOS C57BL
MYCOBACTERIUM LEPRAE
FAGOCITOSE
EXPLOSAO RESPIRATORIA
SUPEROXIDOS
CELULAS DA MEDULA OSSEA/*DE/PH
CELULAS CULTIVADAS
Limites:ANIMAL
Localização:BR191.1; 07046/s


  9 / 10 HANSEN  
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Id:14003
Autor:Peake, P. W; Britton, W. J; Davenport, M. P; Roche, P. W; McKenzie, K. R
Título:Analysis of B-cell epitopes in the variable C-terminal region of the mycobacterium leprae 70-kilodalton heat shock protein
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Fonte:s.l; s.n; 1993. 7 p. tab, graf.
Descritores:SEQUENCIA DE AMINOACIDOS
ANTICORPOS MONOCLONAIS
FORMAÇAO DE ANTICORPOS
LINFOCITOS B
ELISA
EPITOPOS
GENES BACTERIANOS
PROTEINAS DO CHOQUE TÉRMICO
PROTEINAS DO CHOQUE TÉRMICO
HANSENIASE
CAMUNDONGOS
CAMUNDONGOS ENDOGAMICOS BALB C
CAMUNDONGOS ENDOGAMICOS C57BL
CAMUNDONGOS ENDOGAMICOS CBA
CONFORMAÇAO MOLECULAR
DADOS DE SEQUENCIA MOLECULAR
MYCOBACTERIUM LEPRAE
MAPEAMENTO DE PEPTIDIOS
PROTEINAS RECOMBINANTES
PROTEINAS RECOMBINANTES
Localização:BR191.1; 06901/s


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Id:5637
Autor:Turcotte, R; Ishaque, M
Título:Impairment of virulence of in vitro subcultures of Mycobacterium lepraemurium
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Fonte:s.l; s.n; 1983. 3 p. tab.
Descritores:HANSENIASE
MYCOBACTERIUM LEPRAEMURIUM
MICOBACTERIOSE
MICOBACTERIOSE
TÉCNICAS BACTERIOLOGICAS
MEIOS DE CULTURA
CAMUNDONGOS ENDOGAMICOS C3H
CAMUNDONGOS ENDOGAMICOS C57BL
ESPECIFICIDADE DE ESPÉCIES
VIRULENCIA
Localização:BR191.1; 02602/s



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